Moreover, in primary cell sample analysis on comparison of AML samples with normal CD34+ stem and progenitor cells and white blood cells as controls, a preferential decrease in H3K9me3 at core promotor regions is observed in AML blasts, this fundamentally has causal transcription factor changes recruiting varying histone modifying enzymes and altering the chromatin structure (13). The gene discussed is CD34; the disease is acute myeloid leukemia.