TGFB1 and acute myeloid leukemia: Relocation of genes into heterochromatin and transcriptional silencing (4) Involved with resistance to TGFβ signaling in AML (54) Deregulation of direct TGFβ targets p21 and p15—inhibiting cell cycle arrest through constitutive H3K9me3 (55, 56) Physical Interaction with proto—oncogenes (57–60) Creates a binding site for HP1 gene silencing, also allowing DNA methylation (61)