EPAS1 and prostate neoplasm: Figure 9D shows that of the 9 mRNAs in this category, 7 mRNAs are reduced by digitoxin treatment. In addition to Tgfbr2, these include Zeb2, Timp3, Cdh11, Tgfbr2, Wt-1 (Wilm's tumor suppressor gene 1), Axl (Axl receptor tyrosine kinase), and Epas1. Two of the 9 mRNAs are elevated by digitoxin, including Aldh1a and Sfrp4. We also tested the rat prostate tumors for digitoxin effects on Hspb1 and the HSPB1/Rbfox2 ratio.