Platinum-based agents' effects on tumor cells with either wild-type or mutated p53 remain controversial, as some studies have reported that wild-type tumor cells were more sensitive to chemotherapeutic drugs (22), while another study has indicated that [Pt(BDIQQ)]Cl, another kind of platinum-based agent, showed similar cytotoxicity in A549 cells with or without wild-type p53 gene (23). The gene discussed is TP53; the disease is neoplasm.