LGALS1 and rheumatoid arthritis: Previous studies have suggested a possible therapeutic effect after the application of Gal-1 in rat with RA models [17, 29], while another study has shown that galectin-1 expression has been downregulated in juvenile idiopathic arthritis characterized by synovial cell hyperplasia; however, its implication in the physiology of human disease remains unknown [30, 31].