By contrast, we observed no difference in lean body mass (Figure 2D), food consumption (Supplementary Figure S2A) or leptin levels (Supplementary Figure S2B) between WT and Ntn1Δmac mice fed HFD suggesting that macrophage-specific deletion of netrin-1 partly attenuated the development of obesity. This evidence concerns the gene NTN1 and obesity due to melanocortin 4 receptor deficiency.