These divergent responses to netrin-1 are mediated by distinct receptors on target cells: attraction to netrin-1 is mediated by receptors of the DCC (Deleted in Colorectal Carcinomas) family including DCC and neogenin, whereas repulsion or chemostasis are mediated by members of the UNC5 family and the adenosine A2 B receptor (A2BAR) [29]. This evidence concerns the gene NTN1 and colorectal carcinoma.