Although the exact underlying mechanism has yet to be totally known, a preponderance of evidence suggests elevated levels of GDF-15 in various disease conditions including acute coronary syndrome, stable coronary arterial disease, diabetes mellitus, solid cancers, essential HT, left ventricular hypertrophy in HT, atrial fibrillation, and acute and chronic heart failure [8–15]. Here, GDF15 is linked to hematocrit.