Two studies reported from southern India, Tina Thomas et al. (2014), reported that 61% of Hashimoto's thyroiditis presented as diffuse goiter with 93% of them positive for anti-TPO-Ab [8], while Anila KR (2016) reported that nodular form of HT was seen early in the progression of disease, associated with normal TSH and high anti-TPO levels, which became predominantly diffuse later [13]. This evidence concerns the gene TPO and Hashimoto thyroiditis.