The pleiotropic involvement of A-type lamins in all these cellular events explains why mutations in the LMNA gene are the cause of a wide number of disorders, collectively known as “laminopathies,” which may affect one or more specific tissues, including skeletal and cardiac muscles, tendons, adipose tissue, and peripheral neurons, or be systemic causing accelerated ageing [70]. The gene discussed is LMNA; the disease is laminopathy.