In this review, apart from describing the latest advances related to Ankrd2, including an ever-growing interest for Ankrd2 isoform-specific functions, we will report the main findings on Ankrd2 and its relation to lamins and discuss known and potential mechanisms, through which defective Ankrd2-lamin A interplay might have a role in the pathogenesis of LMNA-related muscular disorders. Here, ANKRD2 is linked to muscle tissue disorder.