Finally, a proteomic analysis of Ankrd2 interactome in mature muscle (healthy and EDMD2-affected), as well as the creation of animal models expressing unphosphorylatable Ankrd2 forms, will help to better define the role of Ankrd2 in muscular tissue, allowing the assignment of a specific role of oxidative stress-dependent phosphorylation to the pathology of other cardiac and skeletal muscle disorders. The gene discussed is ANKRD2; the disease is skeletal muscle disorder.