SOD2 and acute myeloid leukemia: To further investigate the PCA-mediated miR-219a-5p/p66shc antioxidant signaling on ALD, AML-12 cells were transfected with the miR-219a-5p agomir in either the presence or absence of PCA with ethanol exposure, and the expression levels of p66shc and MnSOD were determined.