Based on the in vivo findings, AML-12 cells were transfected with si-p66shc, and as anticipated, MnSOD protein expression (Figures 3(a) and 3(b)) and GSH and CAT levels were increased and MDA and H2O2 levels were decreased (Figure 3(d)–3(g)). This evidence concerns the gene CAT and acute myeloid leukemia.