SOD2 and acute myeloid leukemia: Meanwhile, when AML-12 cells were transfected with si-p66shc and ant-219a either together or apart, ant-219a increased the p66shc expression and decreased the MnSOD expression and with p66shc silencing partly alleviated the increase in p66shc and loss in MnSOD (Figure 5(d)–5(f)).