Tang et al. identified 10 hub genes in brain metastasis breast cancer from two GEO databases, and four hub gene expression of which were closely associated with the OS of breast cancer patients by developing an integrated method including GO and KEGG pathway enrichment analysis, PPI network analysis, hub gene identification, transcription factor (TF) analyses, and OS analysis (Tang et al., 2019). Here, TF is linked to breast carcinoma.