The pathways targeted for miRNA-directed suppression at 1 dpi such as focal adhesion and the proteoglycans in cancer pathway could indicate early viral manipulation of host resources linked to documented viral entry strategies involving the binding of host glycoprotein molecules, which have many identities such as cell-surface and transmembrane receptors that make up extracellular matrix proteins such as proteoglycans and integrins (Rabinovich et al., 2012; Cossart and Helenius, 2014). The gene discussed is ART4; the disease is cancer.