CFH and atypical hemolytic-uremic syndrome: Consistently, the common CFH-H3 haplotype, including the T variant of the c.2808G>T (p.Glu936Asp) SNP, predisposes to aHUS, a rare disease characterized by complement-mediated glomerular endothelial injury (Caprioli et al., 2003; Pickering et al., 2007).