ACE and diabetes mellitus: Since the trial found that the ACE inhibitor (ACEi) trandolapril—alone or in combination with verapamil—reduced the risk of progression to microalbuminuria and the number of cardiovascular events (Ruggenenti et al., 2004; Ruggenenti et al., 2012), here we sought to explore whether and to what extent the c.2808G>T (p.Glu936Asp) CFH polymorphism could affect the interactions of diabetes and ACE inhibition with the previously discussed outcomes.