FAP and colon carcinoma: In an effort to design more applicable ways to target FAP, multiple other approaches were developed for the targeting of FAP+ CAFs, including pharmacological inhibitors (e.g., PT630) (121), monoclonal antibodies (FAP5-DM1) (122), a FAP- targeting immunotoxin (αFAP- PE38) (123), and an oral DNA FAP vaccine (124, 125), which showed efficacy in mouse models of breast, pancreatic, lung and colon carcinomas.