However, depletion of FAP+ cells using the DTR system had severe systemic toxicity, including cachexia and anemia in mouse models of transgenic PDAC (KPC mice) and in transplantable colon carcinoma (C26 cells), likely reflecting the importance of FAP+ stromal cells in maintaining normal muscle mass and hematopoiesis (127). The gene discussed is FAP; the disease is anemia (phenotype).