Importantly, recruitment of myeloid cells by CAFs was also shown to be associated with resistance to therapy: In a mouse model of transplantable colorectal carcinoma (CRC), FAPhigh fibroblasts were found to recruit myeloid cells via CCL2, leading to resistance to anti-PD-1 immune checkpoint therapy which was abrogated by targeting FAP. Here, CCL2 is linked to colorectal carcinoma.