Moreover, IL-6 was found to be predominantly expressed in the stroma of human pancreatic tumors, and targeting it in transplantable and transgenic mouse models of pancreatic ductal adenocarcinoma (PDAC) in combination with PD-L1 blockade resulted in attenuated tumor growth, prolonged survival in a transgenic model of PDAC, and increased presence of intratumoral T cells (69). This evidence concerns the gene CD274 and pancreatic neoplasm.