The hybrid cell lines (HU266 and HRC) stimulated significant elevation of IFNγ and perforin releasing cells in response to restimulation with MUC1, CS1, hTERT, and MAGE C1 derived peptide-pulsed T2 cell line, compared with cultured PBMCs without further re-stimulation, the parent myeloma cell line U266, and their parent APC cell line, HMY2 (except for MAGE C1 specific IFNγ releasing response). This evidence concerns the gene IFNG and plasma cell myeloma.