ERN1 and cystic fibrosis: While the only differences we observed in CF PBMCs under basal conditions were IRE1α, GADD34, and IL-6, contrary to the differences found by Blohmke et al. (15), we observed changes in a greater number of transcripts following stimulation with the bacterial component, LPS, suggesting that bacterial infections are the main environmental factors triggering ER stress and inflammation in CF.