ERN1 and TNF receptor 1-associated periodic fever syndrome: For example, dermal fibroblasts from patients with TRAPS fail to upregulate miR-146a and miR-155, due to an increased activity in IRE1, which can be reversed by inhibition of the RNase domain of IRE1α, with 4 μ8c, thereby restoring the levels of miR-146a and miR-155 (21).