While the only differences we observed in CF PBMCs under basal conditions were IRE1α, GADD34, and IL-6, contrary to the differences found by Blohmke et al. (15), we observed changes in a greater number of transcripts following stimulation with the bacterial component, LPS, suggesting that bacterial infections are the main environmental factors triggering ER stress and inflammation in CF. Here, IL6 is linked to bacterial infectious disease.