CD46 and infection: The more frequent, “typical” form of HUS is associated with infections caused by Shiga-like toxin-(verotoxin) producing bacteria, such as enterohemorrhagic E. coli (EHEC), while aHUS is usually linked to mutations in complement proteins (FH, factor I, membrane-cofactor protein/MCP, factor B, C3), thrombomodulin or to antibodies against FH.