PSMB8 and systemic lupus erythematosus: While they observed the most prominent signal in the promoter of the non-coding RNA PSMB8-AS upstream of the PSMB8 gene, we identified in our study of whole blood samples, two neighboring DMCs located between the 3′UTR of PSMB8 and the promoter of TAP2 which were hypomethylated in pSS compared to SLE.