Figure 3A provides two examples of SLE-specific DMCs identified at Fas associated via death domain (FADD, cg08632909) and at hypoxia inducible factor 3 subunit alpha (HIF3A, cg16672562). To further characterize the unique DMCs in SLE, we performed a gene ontology enrichment analysis of the genes harboring SLE-specific differential methylation, and identified hemostasis (p = 3.0 × 10−5), innate immune system (p = 4.0 × 10−5), and FasL/CD95L signaling (p = 8.8 × 10−5) as the most significantly enriched functional pathways specific for SLE (Figure 3B, Supplementary Table S5). Here, FAS is linked to systemic lupus erythematosus.