Interestingly, this same mutation had been previously described as a somatic event in non-small cell lung carcinoma tissue samples, where it was also accompanied by increased Nrf2 nuclear accumulation and by increased mRNA levels of NFE2L2, which is itself a target gene of Nrf2 (25), as well as by increased mRNA levels of the Nrf2 target genes NQO1, and MRP2 (multidrug resistance protein 2) (26). Here, NFE2L2 is linked to non-small cell lung carcinoma.