Therefore, to determine the susceptibility and clinical significance of the NLRP3 inflammasome in ALL, we examined the SNPs of four NLRP3 inflammasome related genes, including NF-κB-94ins/del ATTG, CARD8 (rs2043211), IL-18 (rs1946518), and IL-1β (rs16944). The gene discussed is CARD8; the disease is acute lymphoblastic leukemia.