Some other candidate genes included FKBP5 (a co-chaperone to glucocorticoid receptors as part of the HPA axis leading to stress response regulation and anxiety); the gene encoding the brain-derived neurotrophic factor, BDNF (hypothesized role in mood disorders; Nugent et al., 2011); and the oxytocin receptor gene, OXTR (oxytocin receptors are concentrated in the hypothalamus and dysregulation has been associated with depression and anxiety). This evidence concerns the gene OXTR and mood disorder.