We found a significant increase in the hippocampal levels of IL-1β (Figure 5A) in both HE- and LE-rats exposed to PSD+US in relation to their respective control {HE-PSD+US vs. HE-control, P < 0.0001; LE-PSD+US vs. LE-control, P = 0.0002; two-way ANOVA significant main effect of “stress exposure” [F (1, 33) = 69.63, P < 0.0001]. This evidence concerns the gene IL1B and hereditary elliptocytosis.