Regarding hippocampal IL-4 (Figure 5B), we found increased levels of this cytokine in HE-PSD+US rats relative to HE-control (P = 0.0012), being this increase also significant in relation to LE-PSD+US {P = 0.0103; two-way ANOVA interaction [F (1, 25) = 4.713, P = 0.0396]}. This evidence concerns the gene IL4 and hereditary elliptocytosis.