Furthermore, the levels of these pro-inflammatory mediators are also elevated in the PVN of angiotensin II-induced hypertensive rat models (Kang et al., 2009, 2014; Sriramula et al., 2013; Su et al., 2014), as well as in high salt diet-induced hypertension (Gao et al., 2016; Wang et al., 2018). The gene discussed is AGT; the disease is hypertensive disorder.