NME1 and neoplasm: Several studies showed that NME1/2 intracellular content is correlated with either lowered or enhanced metastatic abilities depending on tissue context of the developing tumor (Steeg et al., 1993; Okabe-Kado et al., 1998; van Noesel and Versteeg, 2004; Tschiedel et al., 2008).