CD80 and autoimmune disease: In autoimmune diseases, DCs as professional APCs have a potent ability to trigger naive T-cell reaction and activate an autoreactive response (Thompson et al., 2018), and decreasing CD80/86 prevented T-cell activation and Th-cell differentiation by inhibiting the costimulatory second signal (Grimbert et al., 2011; Yamamoto et al., 2012).