It was proven that HCQ remitted hepatic steatosis and enhanced insulin sensitivity in the mouse model through decreased adipogenesis, as well as peroxisome proliferator-activated receptor gamma (PPARγ), sterol regulatory element-binding transcription factor 1 (SREBP1c), and carbohydrate response element binding protein (ChREBP) expression in liver tissues of obese mice. This evidence concerns the gene SREBF1 and fatty liver disease.