Although a large number of studies correlate the effect of EPA in pro-inflammatory mediator synthesis via COX-2 inhibition, it must be said that there is a lack of studies about the situation of SPMs in CRC despite the reported deficiency in one of the enzymes with a strong participation on its production, 15-LOX-1, as the largest contributor to the CRC (Shureiqi et al., 2000; Shureiqi et al., 2005). The gene discussed is ALOX15; the disease is colorectal carcinoma.