Synthetic RvD supplementation has shown to improve colitis activity index and reduce body weight loss, colonic damage, PMN infiltration, colonic cytokine levels for TNF-α, IL-1β, MIP-2, CXCL1/KC, and NF-κB phosphorylation, as well as mRNA expression of NF-κB and the adhesion molecules VCAM-1, ICAM-1, and LFA-1 in both models. This evidence concerns the gene NFKB1 and colitis.