Administration of fingolimod protected against neurodegeneration and behavioral effects in mouse PD models induced by MPTP, 6-hydroxydopamine, or rotenone through S1P1 signalling and probably Akt (Ren et al., 2017; Zhao et al., 2017; Motyl et al., 2018); however, the S1P analogue was not effective in a PD model induced by subacute administration of MPTP (Komnig et al., 2018). The gene discussed is S1PR1; the disease is Parkinson disease.