AD brains also showed an increased SK2 activity (Takasugi et al., 2011), and ERK and Fyn kinase, both known modulators of this enzyme, have been implicated in Aβ-mediated neurotoxicity (Olivera et al., 2006; Hait et al., 2007; Crews and Masliah, 2010), which could suggest that SK2 upregulation might be mediated by aberrant phosphorylation by Fyn and/or ERK. The gene discussed is SPHK2; the disease is Alzheimer disease.