Upregulation of SGPL1 and reduced expression of SK1 are detectable in human postmortem brains and in striatal tissues of two of the most commonly used HD animal models (R6/2 and YAC128 mice), even at an early stage of the disease (Di Pardo et al., 2017; Pirhaji et al., 2017). This evidence concerns the gene SGPL1 and Huntington disease.