Ceramide, acting on specific cellular targets (including several signaling protein kinases and phosphoprotein phosphatases) or determining the reorganization of plasma membrane signaling platforms (Zhang et al., 2009), regulates several cellular events, most notably programmed cell death with important consequences in cancer, including inflammation, bacterial infection, and signaling pathways related to Alzheimer’s disease (AD) and other neurodegenerative and neurological disorders (Van Echten-Deckert and Walter, 2012; Czubowicz et al., 2019). The gene discussed is WEE1; the disease is Alzheimer disease.