To investigate how insulin signaling impacts tau pathology, we utilized our well-established model of Tauopathy in which we expressed full-length wild type human Tau (2N4R) in Drosophila eyes using the pan-retinal GMR-GAL4 driver (Jackson et al., 2002; Chatterjee et al., 2009). The gene discussed is MAPT; the disease is tauopathy.