MAPT and tauopathy: Drosophila models misexpressing the full-length human tau have been used successfully by us and many others to recapitulate prominent features of human tauopathies that include progressive neurodegeneration and tau aggregation/phosphorylation at the disease-associated phospho-epitopes mediated by the key kinases (Jackson et al., 2002; Chatterjee et al., 2009).