The exacerbation of tau pathology by Chico-LOF was attributed to insulin resistance as these flies displayed 50% reduction in Drosophila AKT phosphorylated at Serine505 residue that corresponds with insulin resistance in mammalian AKT phosphorylated at Serine473 residue (Standaert et al., 2002). The gene discussed is AKT1; the disease is Insulin resistance.