Dynein mediated transport has been involved in ALS pathogenesis: (i) dynein has been detected in SOD1 aggregates and (ii) alteration of retrograde transport is present in transgenic SOD1-G93A mice even if the legs at odd angles (Loa) mutation in cytopasmic dynein could be protective in transgenic SOD1-G93A mice where it delays disease onset and extends the life span (Kieran et al., 2005; Zhang et al., 2007; Bilsland et al., 2010; El-Kadi et al., 2010). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.