SOD1 and amyotrophic lateral sclerosis: In line with these data is the observation that a viral homologue of HSPB8—the protein ICP10PK, carried by the herpes simplex virus type 2 (HSV-2)—when used to infect the SOD1-G93A ALS rat model is able to delay symptom onset and reduce the progression of the disease, thus enhancing the overall survival of the mice (Aurelian, 2012; Aurelian et al., 2012).