It has been shown that, during disease manifestations and at the end stage of disease, HSPB8 is highly expressed in the spinal cord of the SOD1-G93A ALS mouse model and in spinal cord specimens of ALS patients (Anagnostou et al., 2010; Crippa et al., 2010). This evidence concerns the gene HSPB8 and amyotrophic lateral sclerosis.