Focusing on HSPB1, its role in ALS is rather controversial; for example, HSPB1 overexpression is beneficial when tested in different SOD1-based ALS cell models (Patel et al., 2005; Krishnan et al., 2006; An et al., 2009; Yerbury et al., 2013; Heilman et al., 2017), but animal model experiments did not confirm this protective role. This evidence concerns the gene HSPB1 and amyotrophic lateral sclerosis.