This interpretation is suggested by the finding that, in TDP-43 ALS Drosophila melanogaster models (TDP-43, TDP-35, and TDP-25), the overexpression of the HSPB8 functional ortholog (HSP67Bc) protects from misfolded protein toxicity, while its downregulation has the opposite effect (Crippa et al., 2016a). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.