SOD1 and spinal cord ischemia: In its work, Krishnan et al. (2008) showed that the ubiquitous over-expression of human HSPB1 in SOD1-G93A mice [double transgenic SOD1(G93A)/hHSPB1 mice] did not affect disease duration, progression, motor neuron degeneration or SOD1 aggregation, although hHSPB1 overexpression alone (single transgenic hHSPB1 mice) protected against spinal cord ischemia (Krishnan et al., 2008).