The relevance of the CASA complex in the stress response to proteotoxicity and in neurodegenerative diseases is supported by a large body of evidence, including the finding that genetic mutations of HSPB8 (Irobi et al., 2004, 2010; Ghaoui et al., 2016) and of other three members of this complex have been linked to neurodegenerative or neuromuscular diseases. Here, HSPB8 is linked to neurodegenerative disease.