Several studies have proposed that HSPB8 is implicated both in ALS and SBMA, possibly by acting as a protective agent against disease onset and/or progression (Carra et al., 2005, 2008b, 2010; Crippa et al., 2010, 2013a,b, 2016a,b; Rusmini et al., 2013, 2019; Cristofani et al., 2017, 2018; Cicardi et al., 2018). This evidence concerns the gene HSPB8 and amyotrophic lateral sclerosis.