Specifically, systemic administration of BDNF, NGF, and NT-3 have been reported to enhance neurite outgrowth, neurogenesis, and functional recovery in rodent models of stroke (Grill et al., 1997; Jakeman et al., 1998; Ramer et al., 2000; Winkler et al., 2000; Schäbitz et al., 2004, 2007). The gene discussed is SORT1; the disease is Stroke.