The NLRP3 inflammasome is the most studied type, and genome-wide associated studies show that the mutation in the human NLRP3 gene is linked to hereditary cryopyrin-associated periodic syndrome (CAPS), a spectrum of clinical manifestations including Muckle-Wells syndrome, familiar cold autoinflammatory syndrome, and neonatal-onset multisystem inflammatory disease [17]. Here, NLRP3 is linked to Muckle-Wells syndrome.