IL17A and psoriasis: Greater use of predictive biomarkers may also be important in managing safety risks by precluding treatment of patients unlikely to respond, We note that antidepressants include a black box warning indicating they may increase the risk of suicidal thinking in children and adolescents, and that recently the IL-17 inhibitor brodalumab was approved as a treatment for psoriasis with a warning that it has been linked to suicidal ideation [32].