MYH11 encodes smooth muscle myosin heavy chain, which functions as a major contractile protein, and the variants have been reported to be associated with nonsyndromic thoracic aortic aneurysms and/or dissections (TAADs), patent ductus arteriosus (PDA), acute myeloid leukemia (AML), gastric and colorectal cancer, prostate and breast cancer, and bladder cancer [22–28]. Here, MYH11 is linked to urinary bladder cancer.