In both Cox models for CSS and OS, decreased body mass index (BMI) (p = 0.026 and p = 0.002), Gleason score of ≥9 (p = 0.035 and p = 0.043), extent of bone metastasis (EOD) score of ≥2 (both ps < 0.001), low Hb levels (p = 0.008 and p = 0.004 at baseline and p = 0.002 and p = 0.001 at 2–4 months) and high ALP levels (p = 0.023 and p = 0.046 at baseline and both ps < 0.001 at 2–4 months), high lactate dehydrogenase (LDH) level at baseline (both ps < 0.001), and high PSA level at 2–4 months (both ps < 0.001) were shown to be significant risk factors for worse survival. This evidence concerns the gene KLK3 and bone metastasis.