Our previously identified NPC tumor suppressor genes, Cysteine-Rich Intestinal Protein 2 (CRIP2)11 and Transforming Growth Factor-beta Binding Protein 2 (LTBP2)12, were shown to inhibit the tumor formation by suppressing the canonical NF-κB p65-induced pro-angiogenic and epithelial–mesenchymal transition (EMT) activities. Here, CRIP2 is linked to neoplasm.