IFNG and autoimmune disease: Moreover, the ability of these engineered DCs, multi-ligand DCs particularly, to affect multiple aspects of immune function, viz: higher Treg frequencies and immune regulatory cytokine responses, and lower pro-inflammatory IFNγ responses as well as both IgG2a and IgG1 responses against autoantigen suggests that such tAPCs could have therapeutic value in both T cell mediated and antibody mediated autoimmune diseases.