CCL2 and asthma: In a Brazilian RCT10, a 12-week aerobic training program reduced both BHR and serum proinflammatory cytokines interleukin-6 (IL-6) and monocyte chemoattractant-1 (MCP-1), as well as reduced sputum eosonophils and fractional exhaled nitric oxide (FeNO) in asthma patients with more inflammation.