Based on family studies and next-generation sequencing (NGS), three genes in addition to the established FH genes were identified, in which mutations may be causing significantly elevated LDL-C levels and possibly the clinical phenotype of FH: STAP1 (signal transducing adaptor protein family 1), LIPA (lysosomal acid lipase) and PNPLA5 (patatin-like phospholipase-domain-containing family)21,27,28. The gene discussed is LIPA; the disease is familial hyperaldosteronism.