MACF1 and cancer: Relatively frequent mutations were also detected in several other IntOgen-defined cancer drivers such as MGA, PABPC3, NR4A2, NCOR1 and MACF1 (Fig. 1); of these PABPC3, NR4A2, NCOR1 and MACF1 are detected as mutational cancer drivers in head and neck cancer in IntOgen.