Among all CRC tumors, 225 amplifications (defined as six or more copies) of wt KRAS, 21 of wt NRAS, and 11 of HRAS were observed among 12,711 MT-L tumors, while only one amplification of KRAS and none of NRAS or HRAS were detected in 625 MT-H tumors. Here, HRAS is linked to colorectal carcinoma.