In the hyperlipidemia/hyperlipedimia mice/rats models, it was found that long-term high-fat diets led to the activation/elevation of NADPH Oxidase Catalytic Subunit-Like 3 (NOX3), uncoupling protein 2 (UCP2) and uncoupling protein 3 (UCP3), causing mitochondrial damage and apoptosis in inner ear53,54. Here, NOX3 is linked to hyperlipidemia.