TGFB1 and pancreatic ductal adenocarcinoma: Zhan et al. showed that kindlin-2 is upregulated by TGF-β signalling and that TGF-β1-induced kindlin-2 in turn upregulates TGFBR1, thereby providing positive feedback to drive the progression of pancreatic ductal adenocarcinoma (PDAC) [16].