Similarly, the RING domain has been shown to strongly interact with the Ubc9 E2 SUMO ligase and be fundamental for the SUMOylation process of KAP1 substrates such as the interferon regulatory factor 7 (IRF7) (31) and the neurodegenerative disease driving proteins τ and α-synuclein (32). This evidence concerns the gene IRF7 and neurodegenerative disease.