Similarly, the RING domain has been shown to strongly interact with the Ubc9 E2 SUMO ligase and be fundamental for the SUMOylation process of KAP1 substrates such as the interferon regulatory factor 7 (IRF7) (31) and the neurodegenerative disease driving proteins τ and α-synuclein (32). The gene discussed is UBE2I; the disease is neurodegenerative disease.