MGMT and central nervous system cancer: However, most previous studies on imaging-based prediction of the MGMT promoter methylation status have mainly focused on glioblastomas, and limited studies have included less aggressive gliomas (e.g., lower grade gliomas, such as WHO grade II and III gliomas), in which the MGMT promoter status also has prognostic and predictive value [3–5, 23, 24].