Remarkably, our finding suggested that co-treatment of miR-139- and Afa-incorporated LPN-HR considerably suppressed expression of phosphorylated proteins of EGFR, HER2/3, Akt, mTOR, and STAT3 (Fig. 10g), which supported the inhibitory effect of this formulation on resistant CRC cells accompanying with acquired activation of EGFR/pan-HER family and the related STAT3, PI3K, and KRAS signaling pathways. Here, MTOR is linked to colorectal carcinoma.