ITGAM and obesity due to melanocortin 4 receptor deficiency: The heterogeneity of CD11b+CD45hi cells in our study is likely due to the fact that CD45 is not categorical to separate different subpopulations of myeloid cells—particularly brain-resident vs. peripherally derived—at least in the context of neuroinflammation induced by chronic conditions like obesity, as our flow cytometry data showed continuous levels of CD45 expression across CD11b+CD45+ populations.