APP and Alzheimer disease: Therefore, to determine the similarities and differences between myeloid cell populations in WD-fed mice, AD mice, and aging mice, transcriptional profiles were generated from CD11b+CD45lo and CD11b+CD45hi cells isolated from B6 mice fed the CD from 2 to 20 months, and B6.APP/PS1 mice fed the CD from 2 to 6 months (early plaque deposition in this strain).