Interestingly, the cognate receptor for CD154 is not limited to CD40, and several molecules are considered capable of binding to CD154, such as αIIbβ3, α5β1 (VLA-5) and αMβ2 (Mac-1) integrins, indicating that CD154 is a possible target for the treatment of atherosclerosis [24]. Here, CD40LG is linked to atherosclerosis.