Little is known about the signaling pathways underlying uPAR-mediated angiogenic processes in neovascular eye diseases with the exception of some findings in VEGF-stimulated retinal endothelial cells in which uPAR has been found to mediate the activation of HIF-1 and STAT3 through the involvement of several kinases including JAK1 and members of the MAPK family [108]. The gene discussed is VEGFA; the disease is eye disorder.