(s)UPAR is generated by the proteolytic cleavage of the membrane anchored uPAR and retains most of the uPAR activities; similarly to uPAR, (s)uPAR is involved in cell attachment, motility and migration (for Ref., see [48]) and elevated plasma (s)uPAR is considered as a biomarker in several chronic inflammatory diseases including cancer, cardiovascular diseases, chronic kidney diseases and diabetes [49]. The gene discussed is PLAUR; the disease is chronic kidney disease.