Although a link between the phosphorylation of neural IRS1 at mSer307, mSer612, and mSer632/635 and brain insulin resistance has been proposed [14,16,43], brain insulin resistance is not yet defined, and the phosphorylation of IRS1 at Ser sites emerges in insulin-dependent and insulin-independent manners [5,6]. This evidence concerns the gene IRS1 and Insulin resistance.