VCAN and idiopathic pulmonary fibrosis: Furthermore, an early induction in synthesis of proteoglycans decorin, lumican, biglycan, and versican (Figure 6C, Figure S3), as well as the ECM regulator, TIMP-3, (Figure S3) in IPF scaffolds compared to fibroblasts cultured on healthy scaffolds further strengthen the picture of a promotion of a profibrotic feedback loop.